26. February 2018

The permeability of a powder bed reflects its particle size distribution, shape, packing, porosity, cohesivity, and tensile strength in a manner relevant to powder fluidization. The relationship between the permeability and the performance of carrier-based dry powder inhalation (DPI) mixtures has, however, aroused controversy. The current study sought to gain new insights into the relationship and to explore its potential applications. We studied eight lactose materials as DPI carriers. The...

16. January 2018

We adopt a Quality by Design (QbD) paradigm to better control the mechanical prop- erties of tablets. To this end, the effect of particle size distribution, lubricant concentra- tion, and mixing time on the tensile strength and elastic modulus of tablets is studied. Two grades of lactose, monohydrate and spray-dried, are selected. Tablets are compressed to different relative densities ranging from 0.8 to 0.94 using an instrumented compaction simulator.