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15. April 2016
Background: The objective of the present study was to investigate the combinative effect of ball milling and solvent displacement method on size reduction of Celecoxib particles. Celecoxib is a poorly water soluble cyclooxygenase 2 inhibitor which has a wide range of therapeutic applicability. Methods: Microparticles were developed via solvent displacement method followed by planetary ball milling. In order to obtain an optimized size and size distribution of Celecoxib microparticles various...