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11. March 2015
Abstract Summary Two case studies were conducted to evaluate the material attributes of hypromellose (METHOCEL™ K4M premium cellulose ethers) and Starch 1500® partially pregelatinized maize starch on the performance of extended release (ER) matrices. Variations in the properties of hypromellose K4M had minimal effect on theophylline release profiles, but changes in hydroxypropyl substitution levels (% HP) and particle size of the polymer impacted the drug release from hydrochlorothiazide...