08. April 2016
Aim: The main objective of the present research work was to develop floating microspheres of cefditoren pivoxel (CP) to provide the delivery of the drug at a sustained rate. Materials and Methods: Floating microspheres of CP were prepared by solvent evaporation technique using hydroxypropyl methylcellulose (HPMC) K4M and ethyl cellulose as the rate controlling polymers. The optimization of formulation was carried out by 32 factorial design using two factors; a total amount of polymer (X1) and...
06. April 2016
The aim of this study was to evaluate the potential of twin screw granulation for the continuous production of controlled release formulations with hydroxypropylmethylcellulose as hydrophilic matrix former. Metoprolol tartrate was included in the formulation as very water soluble model drug. A premix of metoprolol tartrate, hydroxypropylmethylcellulose and filler (ratio 20/20/60, w/w) was granulated with demineralized water via twin screw granulation. After oven drying and milling, tablets were...
22. February 2016
By Phil TaylorPhil Taylor, 22-Feb-2016 There are concerns that pharma companies are not fully prepared to meet the new requirements on risk-assessment for excipients, even though the deadline is just a few weeks away. More
25. January 2016
More than 50 percent of people (young and old) have difficulties with the use of tablets and capsules. Difficulty swallowing, psychological barriers against such formats or taste aversions make it hard for the patients to take the prescribed medication reliably. This is why tablets are crushed, dissolved or otherwise altered. Mostly with the result that active ingredients are lost and the dosing quantity is no longer accurate. XStraw® enables the simple and intuitive intake of the exact dosing...
07. January 2016
The present investigation studied a novel bilayer tablet having extended release of rosuvastatin calcium (RSTCa) and immediate Release of fenofibrate (FB) in different polymers using wet granulation techniques. Granules were characterized by fourier-transformed Infrared Spectroscopy (FT-IR), differential Scanning Calorimetry (DSC), as well as by content uniformity, in-vitro dissolution studies and release kinetics. Selected granular system was subjected to bilayer tablet preparation by direct...
22. December 2015
To design a novel preactived carboxymethyl cellulose derivative. Methods: First, carboxymethyl cellulose (CMC) was chemically modified by amide bond formation between primary amino group of cysteine (CYS) and carboxylic moiety of CMC mediated by carbodiimide. Second, obtained CMCCYS was preactivated with 2,2′-dithiodinicotinic acid. Designed CMC-S-S-MNA was characterized by FT-IR. Furthermore, cytotoxicity was conducted on Caco-2 cell line. Swelling behavior, erosion and release of novel...
30. November 2015
Multiparticulate dosage forms are a recent strategy to meet the special needs of children, elderly people and patients suffering from dysphagia. Our study presents a novel and cost-efficient approach for the manufacturing of a taste-masked multiparticulate system with a stable immediate release profile by applying lipid-based excipients in a solvent-free hot melt coating process. More
17. September 2015
It is known that some drugs behave differently in men and women; indeed, gender plays a crucial role in pharmacokinetics, pharmacodynamics and drug toxicity. Differences in metabolism and clearance of drugs as a consequence of distinct hepatic and renal processes in males and females are now much better understood, though little is still known about gender differences in the gastrointestinal tract. More