05. December 2017
INSTACOAT™ 4G, a high solids, low viscosity formulation allows coating across a broad range of process parameters in any type of a coating equipment. It significantly reduces coating process time and delivers coated tablets with good surface finish. This study evaluates coating uniformity and tablet appearance of Instacoat 4G™ in a fully perforated Bectochem perforated pan.
26. September 2017
In general, it is an important criterion that excipients remain inert throughout the shelf life of the formulated pharmaceutical product. However, depending on the functionality in chemical structure of active drug and excipients, they may undergo interaction.
08. August 2017
The process of drying thin polymer films is an important operation that influences the film structure and solid state, and the stability of the product. The purpose of this work was to study and model the drying kinetics of multicomponent films based on two polymers: hydroxypropyl methylcellulose (HPMC, amorphous) and polyvinyl alcohol (PVA, semicrystalline).
07. August 2017
The International Pharmaceutical Excipients Council (IPEC) Foundation announced the 2017 award season winners, who will be recognized for their contributions to the field of excipients during the American Association of Pharmaceutical Scientists (AAPS) Annual Meeting at the San Diego Convention Center in San Diego, CA, on November 13-15, 2017.
03. July 2017
As an industry, we are uncovering ways to treat more complex targets, develop precision medicines, and advance transformative therapies.
28. February 2017
BY: ASHLEY JOHNSON Recently, there has been increasing interest in using 3D printing (3DP) to manufacture drug products. Notably, in 2015, the Food and Drug Administration (FDA) approved the first 3D printed tablet, Aprecia Pharmaceutical’s Spritam for the treatment of epileptic seizures. Spritam is fabricated using the company’s ZipDose 3DP technology, which creates porous tablets that dissolve almost instantaneously in the mouth. In 2016, FDA released draft guidance for submission of...
22. January 2017
Abstract Peptides and proteins represent a promissory group of molecules used by the pharmaceutical industry for drug therapy with great potential for development. However, the administration of these molecules presents a series of difficulties, making necessary the exploration of new alternatives like the buccal route of administration to improve drug therapy compliance. Although drop-on demand printers have been explored for small molecule drugs with promising results, the development of...
31. December 2016
The powder blending process is often identified as a challenging operation in solid dosage form manufacturing. On one hand, inadequate blending leads to poor active ingredient/excipient mixing. On the other hand, excessive blending could potentially deleteriously affect the drug content uniformity the final product. Mixing behavior is complex and can be affected by various chemical and physical properties of the solid materials like density, particle size, particle shape, and surface energy....
31. December 2016
Bioavailability of a poorly water-soluble drug can be improved by preparing its aqueous nanosuspension in the presence of various stabilizers via wet milling and subsequently drying the suspension into nanocomposite microparticles or shortly nanocomposites. Unfortunately, drug nanoparticles aggregate during milling and drying, causing incomplete recovery and relatively slow dissolution from the nanocomposites. While various stabilizers/dispersants can be used to mitigate the extent of...
16. December 2016
Utilization of a Moisture Barrier Film Coating to Enhance In-Use Tablet Stability Plinio Sandoval, David Ferrizzi, Jason Teckoe, Charles Cunningham and Ali Rajabi-Siahboomi Examination of Coating Process Adaptability Using Opadry® QX in the GEA ConsiGma™ Coater Charles Cunningham, Andrew Birkmire, Sean Gillian Investigation of Plasticizer Selection for Extended Release Multiparticulates Using Powder Layering with Novel High Productivity Grade of Ethylcellulose Raxit Y. Mehta, Nick Grasman,...