17. February 2018

Abstract Pharmaceutical excipients were designed originally to be pharmacologically inert. However, certain excipients were found to have altering effects on drug pharmacodynamics and/or pharmacokinetics. Pharmacokinetic interactions may be caused by modulation of efflux transporter proteins, intercellular tight junctions and/or metabolic enzyme amongst others. In this study, five disintegrants from different chemical classes were evaluated for P-glycoprotein (P-gp) related inhibition and tight...

13. February 2018

As an essential formulation component for large-scale tablet manufacturing, the lubricant preserves tooling by reducing die-wall friction. Unfortunately, lubrication also often results in adverse effects on tablet characteristics, such as prolonged disintegration, slowed dissolution, and reduced mechanical strength.

17. January 2018

Controlled release dosage forms are essential in certain dosage regimens where release rate of drug impacts the effectiveness for therapy. In the present study, modified release dosage form of Domperidone was developed in the form of pellets which were subsequently compressed into tablet to disintegrate and swallow by patients without changing the release profile.