Posts tagged with "Aceclofenac"


08. March 2017

Modulation of microenvironmental pH for dual release and reduced in vivo gastrointestinal bleeding of aceclofenac using hydroxypropyl methylcellulose-based bila

Abstract This study was designed to develop a once-daily controlled-release matrix tablet of aceclofenac 200 mg (AFC-CR) with dual release characteristics and to investigate the role of an alkalizer in enhancing drug solubility and reducing the occurrence of gastroduodenal mucosal lesions. Two formulation approaches were employed, namely a monolithic matrix tablet and a bilayered tablet. In vitro dissolution studies of AFC-CR tablets were carried out in simulated intestinal fluid (pH 6.8...

Read more...

18. October 2016

Dual release and molecular mechanism of bilayered aceclofenac tablet using polymer mixture

Abstract The objectives of the present study were to develop a controlled-release bilayered tablet of aceclofenac (AFN) 200 mg with dual release and to gain a mechanistic understanding of the enhanced sustained release capability achieved by utilizing a binary mixture of the sustained release materials. Different formulations of the sustained-release layer were formulated by employing hydroxypropyl methylcellulose (HPMC) and hydroxypropyl cellulose (HPC) as the major retarding polymers. The in...

Read more...

27. October 2015

Development of novel multifunction directly compressible co-processed excipient by melt granulation technique

Read more...

18. June 2015

Formulation Development, in Vitro Evaluation and Stability Study of Aceclofenac Tablet - Article

Read more...

05. February 2015

Design of bilayer tablets using modified Dioscorea starches as novel excipients for immediate and sustained release of aceclofenac sodium

Read more...