13. September 2018
This work demonstrates the feasibility of the extemporaneous preparation of maltodextrins orodispersible films (ODF) by hot-melt ram-extrusion 3D printing. This method consists of three simple technological operations which can be also implemented in a pharmacy setting. First, maltodextrins, drug, and other excipients are mixed in a mortar and wetted with the plasticizer (i.e. glycerine). Then, the mixture is fed in the chamber of the ram-extruder and heated. ODF are individually printed on the...
22. June 2016
Summary This study investigated the effect of polyvinylpyrrolidone (PVP) on a film containing carboxymethyl cellulose sodium (CMC) as a matrix to improve surface roughness caused by drug recrystallization. Acetaminophen (AA) was used as the model drug. Recrystallization is a problem encountered during the preparation of films that contain high drug doses, making them difficult to take. A film that does not disintegrate for clinical applications requires a smooth surface, moderate strength and...
15. March 2016
A new formulation has been developed successfully, which includes production of highly-porous mannitol particles with high surface areas through the spray drying of mannitol solutions containing ethanol-soluble sugar or food-grade acids as templating agents. The resultant porous particles after ethanol washing have been transferred to ethanol solutions containing the drug component. The results of this study showed that deposition of acetaminophen in the pore-space of highly-porous mannitol...
15. January 2016
A new formulation method for solid dosage forms with drug loadings from 0.65 ± 0.03% to 39 ± 1% (w/w) of acetaminophen (APAP) as a model drug has been presented. The proposed method involves the production of highly-porous lactose with a BET surface area of 20 ± 1 m2/g as an excipient using a templating method and the incorporation of drug into the porous structure by adsorption from a solution of the drug in ethanol. More
13. January 2016
Ethylcellulose is one of the most commonly used polymers to develop reservoir type extended release multiparticulate dosage forms. For multiparticulate extended release dosage forms, the drug release is typically governed by the properties of the barrier membrane coating. The ICH Pharmaceutical Development Guideline (ICH Q8) requires an understanding of the influence of critical material attributes and critical process parameters on the drug release of a pharmaceutical product. More
28. February 2015
Justin L. Quon , Keith Chadwick , Geoffrey P. F. Wood , Iris Sheu , Blair K. Brettmann , Allan S. Myerson, and Bernhardt L. Trout * Novartis-MIT Center for Continuous Manufacturing and Department of Chemical Engineering, Massachusetts Institute of Technology, 77 Massachusetts Avenue, E19-502b, Cambridge, Massachusetts 02139, United States Langmuir, 2013, 29 (10), pp 3292–3300 DOI: 10.1021/la3041083 Publication Date (Web): February 17, 2013 Copyright © 2013 American Chemical Society *E-mail...