08. June 2016

Isotretinoin was formulated in novel micro emulsion based gel formulation with the aim of improving its solubility, skin tolerability, therapeutic efficacy, skin-targeting efficiency and patient compliance. Micro emulsion was formulated by the spontaneous micro emulsification method using 8 % isopropyl myristate, 24 % Labrasol, 8 % plurol oleique and 60 % water as an external phase. All plain and isotretinoin-loaded micro emulsions were clear and showed physicochemical parameters for the...