27. August 2018
Affinisol® (Hydroxypropylmethyl cellulose) polymers with low glass-transition temperature are usually processed by Melt Extrusion and show better compressibility at lower compression pressure. This study evaluates the compaction properties and powder properties of Affinisol® Powder by the determination of physical properties like bulk/tapped density, angle of repose and loss on drying, an out-of-die compactability, axial expansion post-compression, effect of compression force on hardness of...
19. February 2018
Solubility is the biggest challenge in the drug formulation processes. Register for the webinar Feb. 22, 11 AM EST as Kevin O'Donnell and I introduce our AFFINISOL™ and ENTERACT™ polymers for solubility enhancement and enteric delivery. http://bit.ly/2svU5Kq More on Dow Pharma Solutions
14. December 2017
Dow Pharma Solutions demonstrated its commitment to advancing the pharmaceutical sciences by exhibiting research findings in a range of posters at the 2017 AAPS show in San Diego, CA. Please find below links to copies of our presented posters.
17. August 2017
AFFINISOL™ HPMC HME of varied viscosity was successfully processed with Itraconazole into homogenous amorphous solid dispersions.
09. June 2017
The formation of molecularly dispersed amorphous solid dispersions by the hot-melt extrusion technique relies on the thermal and mechanical energy inputs, which can cause chemical degradation of drugs and polymeric carriers.
22. November 2016
INTRODUCTION In recent years, the use of 3D printing (3DP) for formation of custom dose forms has received increasing research interest for pharmaceutical applications. To date limited API loadings have been achieved. Current fused deposition modelling (FDM) approaches utilise a formulated filament (e.g. polymer and active) as a feedstock which can be made by hot-melt extrusion (HME). One key purpose of this work is to explore methods of achieving developing a viable routes to establishing...
05. July 2016
This technical paper studies the impact of extrusion process parameters on the performance of solid dispersions of Ritonavir, a poorly soluble antiretroviral drug, and AFFINISOL (TM) HPMC HME, a new grade of HPMC designed for hot melt extrusion. The formulation with a fixed drug: polymer ratio was extruded at different processing conditions exploring the variables of feed rate, screw speed and temperature for their impact on drug degradation, its physical state and dissolution performance of...
18. October 2015
Oct 15, 2015 By Pharmaceutical Technology Editors At CPhI Worldwide 2015, The Dow Chemical Company announced the global commercial availability of AFFINISOL HPMC HME, a new generation of cellulosic polymer for drug solubilization. The polymer is designed for use by pharmaceutical companies looking to enhance the solubilization and inhibit the recrystallization of APIs in hot-melt extrusion (HME) formulations. The product’s ability to overcome solubilization of poorly soluble APIs addresses...