20. March 2017

ABSTRACT The study carried out here was focused on developing conventional monolithic controlled release matrix tablet of Atorvastatin calcium using carbomer as release controlling polymer. This system ensures the drug release at the alkaline pH region where the drug has got maximum solubility. Further the study was concentrated on comparing the impact of gelling agent polyvinyl pyrrolidone on drug release. Quality by design tools were considered during formulation development and the polymer...

04. November 2016

γ-Cyclodextrin (γCD) is a cyclic oligosaccharide formed by bacterial digestion of starch and used as solubilizing agent and stabilizer in a variety of pharmaceutical and food products. γCD is a large (molecular weight 1297 Da) hydrophilic molecule that does not readily permeate biological membranes and is rapidly digested by bacteria in the gastrointestinal tract. In humans γCD is metabolized by α-amylase that is found in, for example, saliva, bile fluid and tears. Thus, bioavailability of...

21. March 2016

The development of oral controlled release system has been a challenge to formulation scientist due to their inability to restrain and localize the system at targeted areas of the gastrointestinal tract. Various physical and chemical approaches have been applied to produce a well characterized dosage form that controls drug input into the body within the specifications of the desired release profile. This is generally accomplished by attempting to obtain “zero-order” release from the dosage...

23. December 2015

Purpose of this study was to investigate the ability of octenyl succinic anhydride (OSA) starch as emulsifier and solid carrier in dry emulsion (DE) and dry suspension (DS) formulations. Fenofibrate (FF) was loaded at lower and higher than its saturation concentration in oil phase to prepare the DE and DS by spray drying method. More

08. December 2015

30. November 2015

Itraconazole (ITZ) is a broad spectrum triazole antifungal drug and commercially available as oral forms. However, effective topical forms are interesting to avoid systemic adverse effects, to directly deliver antifungal drugs to the target sites and to enhance patient compliance [1]. Microemulsion-based hydrogel (MBH), semisolid form of microemulsion (ME), is one of novel formulations practically used as topical drug carriers [2]. This study aimed to develop formulations of ITZ-loaded MBHs...

04. June 2015

Presentation and Research Paper presented at the PharmaLunch May, 2015 of the Swiss Academy of Pharmaceutical Sciences in Basel, Switzerland Steven Taub, Research and Development Manager, Cardiovascular Surgery Department, Centre Hospitalier Universitaire Vaudois, CHUV, Lausanne More information and downloads