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16. February 2017
ABSTRACT Amiodarone is antihypertensive drug with variable bioavailability following oral administration due to poor solubility and pre-systemic metabolism. Accordingly, the study strategy was to enhance the dissolution rate of the drug by solid dispersion (SD) and surface solid dispersion (SSD) techniques, with optimum formulations being developed as fast disintegrating tablets with rapid release. Binary and ternary SD were prepared using Pluronic F68, Pluronic F127 and PVP k30 as the...