Posts tagged with "Antagonist"


07. January 2017

Simultaneous Formulation Development, Evaluation and Estimation of Innovative Controlled Release Tablets of Bosentan Formulated with Varied Polymers

ABSTRACT: Bosentan is an endothelial receptor antagonist (ERA) indicated for the treatment of Pulmonary arterial hypertension (PAH). The aim of the present study involves the development of controlled release tablets of bosentan1. The tablets were prepared to release the drug for a prolong period of time within the GIT, to enhance the bioavailability, to minimize the dosing frequency, and to improve the patient compliance2. The tablets were formulated by using various polymers like hydroxyl...

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28. August 2016

Sublingual fast dissolving niosomal  films for enhanced bioavailability and prolonged effect of metoprolol tartrate

Abstract: The aim of the present work was to prepare and evaluate sublingual fast dissolving lms containing metoprolol tartrate-loaded niosomes. Niosomes were utilized to allow for pro- longed release of the drug, whereas the lms were used to increase the drug’s bioavailability via the sublingual route. Niosomes were prepared using span 60 and cholesterol at different drug to surfactant ratios. The niosomes were characterized for size, zeta-potential, and entrapment ef ciency. The selected...

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26. November 2015

Preparation and Evaluation of Fixed Combination of Ketoprofen Enteric Coated and Famotidine Floating Mini Tablets by Single Unit Encapsulation System

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28. June 2015

New Formulation of Sustained Release Naloxone Can Reverse Opioid Induced Constipation Without Compromising the Desired Opioid Effects - Abstract

An international double-blind randomized placebo controlled study evaluated the safety and efficacy of four doses of a new sustained release naloxone capsule to treat Opioid Induced Constipation (OIC). More

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