05. July 2018
Antimicrobial resistance and its resulting dire consequences have finally become well recognized. Still, the problem continues to proliferate, killing thousands each year. Bacteria are amazingly resilient and will over time develop resistance to whatever we throw their way trying to kill them. But this is only half of the underlying reason for the problem and the half that we can’t do anything about. The other half of the reason is that the economic model for anti-infective drug development...
23. April 2018
The aim of this study is to investigate the influence of excipients on physical and aerosolization stability of spray dried Ciprofloxacin dry powder inhaler formulations. The model drug, Ciprofloxacin hydrochloride, was co-spray dried with excipients such as disaccharides (sucrose, lactose, trehalose), mannitol and L-leucine. The spray dried samples were stored at two different relative humidity (RH) conditions of: (1) 20% and (2) 55% RH at 20°C. Ciprofloxacin co-spray dried with disaccharides...
26. January 2018
The last fifty years, ophthalmic drug delivery research has made much progress,
challenging scientists about the advantages and limitations of this drug delivery approach. Topical eye
drops are the most commonly used formulation in ocular drug delivery. Despite the good tolerance
for patients, this topical administration is only focus on the anterior ocular diseases and had a high
precorneal loss of drugs due to the tears production and ocular barriers. Antibiotics are popularly
used in solution
07. October 2017
SYN-004 (ribaxamase) delayed release drug product is a multi-particulate, hard capsule for oral delivery of a recombinant β-lactamase enzyme designed to degrade β-lactam antibiotics administered intravenously, and thus prevent colon dysbiosis. Here we describe the development of the SYN-004 enteric coated pellet formulation, which has been tested in multiple clinical trials. Since the SYN-004 drug substance is a buffered liquid, several binder excipients in different ratios were tested to...