18. April 2017

Abstract The structural changes of crystalline atorvastatin upon high-energy ball milling at room temperature have been studied. The study investigates the effect of polyvinylpyrrolidone (PVP) and hydroxypropylmethyl cellulose (HPMC) polymeric matrix on stabilizing amorphous atorvastatin before and after storage under ambient and elevated humidity conditions. The materials were characterized by X-ray diffraction (XRD), Fourier transform infrared spectrophotometry (FTIR), differential scanning...

20. March 2017

ABSTRACT The study carried out here was focused on developing conventional monolithic controlled release matrix tablet of Atorvastatin calcium using carbomer as release controlling polymer. This system ensures the drug release at the alkaline pH region where the drug has got maximum solubility. Further the study was concentrated on comparing the impact of gelling agent polyvinyl pyrrolidone on drug release. Quality by design tools were considered during formulation development and the polymer...

02. May 2016

To improve the dissolution and oral bioavailability (BA) of atorvastatin calcium (ATV), we previously introduced an optimized self-microemulsifying drug delivery system (SMEDDS) using Capmul® MCM (oil), Tween® 20 (surfactant), and tetraglycol (cosurfactant). In this study, various solid carriers were employed to develop a solidified SMEDDS (S-SMEDDS): mannitol (M) and lactose (L) as water-soluble carriers, and Sylysia® 350 (S) and Aerosil® 200 (A) as water-insoluble carriers. Maximum...

13. December 2015

The purpose of this study was to develop mesoporous silica materials incorporated with poorly water-soluble drug atorvastatin calcium (AC) in order to improve drug dissolution, and intended to be orally administrated. A comparison between 2D-hexagonal silica nanostructured SBA-15 and mesocellular siliceous foam (MSF) with continuous 3D pore system on drug release rate was investigated. More

06. December 2015