29. May 2018
The delivery of probiotics to different sites of action within the human body might help to prevent and treat several diseases. Here, we describe a microcapsule-based system for delivery of probiotic bacteria, as vegetative cells or spores, which promotes their prolonged survival and efficient revival, and successful colonisation of the target surface. This system is proposed for local delivery into periodontal pockets. Encapsulation of the probiotic bacteria was based on alginate crosslinking...
10. March 2018
Mucoadhesive tablets for administration in buccal mucosa are unconventional formulations with many technological attractions. However there is no standardization of information for its formulation. The present article aims to evaluate, by means of a systematic review with meta-analysis, the data related to the final quality of this technology.
01. November 2017
Gums from Enterolobium cyclocarpum and Cedrela odorata trees were evaluated in formulating bioadhesive microspheres containing metformin hydrochloride, for sustained drug release. Hydroxylpropyl- methyl cellulose (HPMC) was the standard.
09. October 2017
Tablets with HPMC/CH are the most suitable for vaginal controlled release of TFV.
HPMC/CH tablets show vaginal mucoadhesion time according to the TFV release time. A higher proportion of CH than HPMC has a moderate swelling and faster erosion
27. February 2017
Abstract: The main challenges facing efforts to prevent the transmission of human immunodeficiency virus (HIV) are the lack of access to sexual education services and sexual violence against young women and girls. Vaginal formulations for the prevention of sexually transmitted infections are currently gaining importance in drug development. Vaginal mucoadhesive tablets can be developed by including natural polymers that have good binding capacity with mucosal tissues, such as chitosan or guar...
21. June 2016
Abstract Mucoadhesive microparticles formulated in a capsule and delivered to the gastrointestinal tract might be useful for local drug delivery. However, swelling and agglomeration of hydrophilic polymers in the gastrointestinal milieu can have a negative influence on particle retention of mucoadhesive microparticles. In this work, we investigated the impact of dry-coating with nano-sized hydrophilic fumed silica on dispersibility and particle retention of mucoadhesive microparticles. As a...
08. February 2016
Mucoadhesion, the state in which two materials, amongst which one is biological in nature, adhere to each other for extended periods of time with the help of interfacial forces, provides an attractive strategy to overcome the hurdles of conventional drug delivery systems including first pass metabolism, and localized delivery of biomolecules including proteins, peptides and oligonucleotides. Mucoadhesion provides great opportunities for the delivery of a variety of compounds via different...