30. March 2017

Abstract Chitin is one of the most abundant natural polymers in the world and is used for the production of chitosan by deacetylation. Chitosan is nontoxic and biodegradable and, therefore, can be used as a biomaterial and for the construction of drug delivery systems. Nevertheless, the poor solubility of chitosan in neutral or alkalinized media has restricted its applications in the pharmaceutical and biomedical fields. Chitosan can be easily carboxymethylated to improve its solubility in...

06. February 2017

Abstract The aim of this study was to develop mucoadhesive pellets on a thiolated pectin base using the extrusion-spheronization technique. Thiolation of pectin was performed by esterification with thioglycolic acid. The molecular weight and thiol group content of the pectins were determined. Pellets containing pectin, microcrystalline cellulose and ketoprofen were prepared and their mucoadhesive properties were evaluated through a wash-off test using porcine intestinal mucosa. The in vitro...

26. February 2016

Extracted propolis has been used for a long time as a remedy. However, if the release rate of propolis isnot controlled, the efficacy is reduced. To overcome this issue, extracted propolis was added to a cryogen system. Propolis collected from southern Brazil was extracted using different methods and loaded at different concentrations into polyvinyl alcohol (PVA) and polyacrylic acid hydrogels as carrier systems. The material properties were investigated with a focus on the propolis release...

16. February 2016

Oceans are a vast source of natural substances. In them, we find various compounds with wide biotechnological and biomedical applicabilities. The exploitation of the sea as a renewable source of biocompounds can have a positive impact on the development of new systems and devices for biomedical applications. Marine polysaccharides are among the most abundant materials in the seas, which contributes to a decrease of the extraction costs, besides their solubility behavior in aqueous solvents and...

18. July 2015

Phase-sensitive in situ forming implants (ISFI) are a promising platform for the controlled release of therapeutic agents. The simple manufacturing, ease of placement, and diverse payload capacity make these implants an appealing delivery system for a wide range of applications. More

25. February 2015

Mesoporous Biomaterials is an international, peer-reviewed journal that publishes original research, as well as authoritative review and opinion papers dealing with the main issues in the use of porous material properties, including new fabrication approaches, and reporting the advances of these materials in photonic, electronic, optoelectronics, and biomedical applications... http://www.degruyter.com/view/j/mesbi.2015.2.issue-1/issue-files/mesbi.2015.2.issue-1.xml