01. November 2017

A two factor three level factorial design was used to investigate the effects of carbopol and cationic hydrophilic polymerswhich have a common use in buccal drug formulations. Statistical modelswith interaction terms were derived to evaluate influence of carbopol(X1) and chitosan (X2) on tablet disintegration (Y1) and dissolution(Y2), mechanical properties (Y3), swelling (Y4).