10. March 2018
Mucoadhesive tablets for administration in buccal mucosa are unconventional formulations with many technological attractions. However there is no standardization of information for its formulation. The present article aims to evaluate, by means of a systematic review with meta-analysis, the data related to the final quality of this technology.
15. January 2018
Polysaccharides are natural polymers, or biopolymers with broad spectrum of applications due to their capability of modifying the solution properties by thickening, gelation, emulsification, stabilization, encapsulation, flocculation, swelling and gel formation.
11. July 2017
This article discusses the range of outcomes from biopharmaceutical studies of specific modified release (MR) product examples in preclinical models and humans.
11. May 2017
Established in 2008 and now celebrating our 10th consecutive year, the scope of BOS cmc 2017 will cover development stage CMC outsourcing for both small molecules and biologics (including novel therapeutic entities such as cell therapies and gene therapies). Our programme is divided into small molecule and biologics tracks and includes the following modules: Outsourcing Business Process: Building Effective Outsourcing Partnerships: Early Development Outsourcing: Late Stage Outsourcing: Drug Deli
17. November 2016
Abstract Orally Disintegrating Tablets (ODT) have the advantages of both solid dosage form specially the stability and ease of handling and liquid dosage forms including ease of swallowing and pre-gastric absorption. We focused on taste masking and formulation of ranitidine ODT which disintegrates rapidly in the mouth within 60 sec using super-disintegrants, special polymers, water soluble and even insoluble excipients, sweeteners and essence. Various formulations were designed and made in four...
16. November 2016
Orally Disintegrating Tablets (ODT) have the advantages of both solid dosage form specially the stability and ease of handling and liquid dosage forms including ease of swallowing and pre-gastric absorption. We focused on taste masking and formulation of ranitidine ODT which disintegrates rapidly in the mouth within 60 sec using super-disintegrants, special polymers, water soluble and even insoluble excipients, sweeteners and essence. Various formulations were designed and made in four series....
08. May 2016
The aim of the current study was to formulate and evaluate glipizide controlled release matrix tablets by means of different grades of polymer Ethoceland different co-excipients in order to evaluate their effect on drug release profiles during in vitro dissolution studies. Type II diabetes mellitus is usually treated with Glipizide. Glipizide belongs to sulfonylurea group. Gastric disturbance and severe hypoglycemia has been observed after taking glipizide orally. To overcome these problems,...
15. March 2016
Thiocolchicoside used for the effective treatment of muscle spasm, cramps, musculoskeletal and neuromuscular disorders. It is available in market in the form of capsules and injection. The major problem associated with thiocolchicoside is it's bioavailability which is very low i.e. 25-30% only so in order to minimize drug loss due to first pass metabolism, and overcome problem associated with low bioavailability of drug there is a need to formulate semisolid preparation in the form of gel so we...
22. December 2015
To design a novel preactived carboxymethyl cellulose derivative. Methods: First, carboxymethyl cellulose (CMC) was chemically modified by amide bond formation between primary amino group of cysteine (CYS) and carboxylic moiety of CMC mediated by carbodiimide. Second, obtained CMCCYS was preactivated with 2,2′-dithiodinicotinic acid. Designed CMC-S-S-MNA was characterized by FT-IR. Furthermore, cytotoxicity was conducted on Caco-2 cell line. Swelling behavior, erosion and release of novel...