16. March 2018
This year's Swiss Pharma Science Day is focused on Cancer with the following presentations: «National Strategy Against Cancer» Dr. sc.nat. Michael Röthlisberger, Nationale Strategie gegen Krebs, Krebsliga, Bern «Non-biological Complex Nanomedicines and Their Preclinical Evaluation» Dr. Scott McNeil, NCL-NCI Frederick MD, U.S.A. «Lessons to be Learned: The Molecular Basis of Kinase-Targeted Therapies and Drug Resistance in Non-Small Cell Lung Cancer» Prof. Dr. Daniel Rauh, TU Dortmund...
18. January 2018
Medicinal cannabis is prescribed under the provision of a controlled drug in the Australian Poisons Standard. However, multiple laws must be navigated in order for patients to obtain access and imported products can be expensive. Dose-response information for both efficacy and toxicity pertaining to medicinal cannabis is lacking.
02. April 2017
Abstract Artemisinin, a natural anti-malarial agent, also possesses anti-proliferative and anti-angiogenic activity in cancer cells with very low toxicity to normal healthy cells. Drug loaded magnetic nanoparticlesby using external magnetic field could selectively accumulate the drug at the target site and thereby reduce the doses required to achieve therapeutic concentration which may otherwise produce serious side effects on healthy cells. In the present study the artemisinin magnetic...
22. November 2016
Elacridar is an inhibitor of the permeability glycoprotein (P-gp) and the breast cancer resistance protein (BCRP) and is a promising absorption enhancer of drugs that are substrates of these drug-efflux transporters. However, elacridar is practically insoluble in water, resulting in low bioavailability which currently limits its clinical application. We evaluated the in vitro dissolution and clinical pharmacokinetics of a novel amorphous solid dispersion (ASD) tablet containing elacridar. The...
18. October 2016
Abstract The present study focuses on the development of dry powders for inhalation as adjuvant chemotherapy in lung cancer treatment. Cisplatin was chosen as a potential candidate for a local treatment as it remains the main platinum component used in conventional chemotherapies, despite its high and cumulative systemic toxicities. Bulk cisplatin was reduced to submicron sizes using high-pressure homogenization, mixed with a solubilized lipid and/or PEGylated component and then spray-dried to...
03. May 2016
This research has investigated over different parameters and combined the additional anti-cancerous properties of high ester pectin based formulation, which exhibit almost negligible degradation by colonic bacteria. In present investigation compression coated tablets were prepared using high ester pectin derived from Mangifera indica fruit peel for colon specific delivery of 5-Fluorouracil. Pectin was extracted from dried fruit peel powder of Mangifera indica using water acidi ed with 0.2 M...
30. January 2016
Smart polymer nanogel-assisted drug delivery systems have attracted more and more attention in cancer chemotherapy because of their well-defined morphologies and pleiotropic functions in recent years. In this work, an L-cystine-crosslinked reduction-responsive polypeptide nanogel of methoxy poly(ethylene glycol)-poly(L-phenylalanine-co-L-cystine) (mPEG-P(LP-co-LC)) was employed as a smart excipient for RM-1 prostate cancer (PCa) chemotherapy. Doxorubicin (DOX), as a regular chemotherapy drug,...
23. January 2016
With Quality by Design (QbD), a systematic approach involving design and development of all production processes to achieve the final product with a predetermined quality, you work within a design space that determines the critical formulation and process parameters. Verification of the quality of the final product is no longer necessary. More