02. August 2016
Highlights • Carnauba wax was exploited as a novel excipient for melt granulation. • Melt granulation improved tabletability and flowability of both captopril and metformin HCl. • Sustained release of captopril was achieved by Ethocel™ at a 50% (w/w) concentration. • Sustained release of metformin HCl was reached by film-coating (Kollicoat® SR 30D: Opadray® II). • Carnauba wax assisted sustaining the drug release in conjunction with the polymers. More
10. March 2016
Purpose: To develop gastro-resistant multiparticles systems for mesalazine colon delivery capable to facilitate the dispersion in water and the intake by children. Method: Mesalazine microparticles, containing stearic acid, carnauba wax and Eudragit L®, were obtained by spray-congealing. “Excipient microparticles” of mannitol/lecithin were prepared by spray-drying. Mesalazine lipid microparticles, non-agglomerating per se, were agglomerated by blending in turbula with mannitol/lecithin...
10. March 2016
ABSTRACT Six batches of formulated sustained release matrix tablets of Cefixime Trihydrate were prepared by using different polymers like Tamarind Gum, Carnauba wax, HPMC, MCC, PVP K30 by wet granulation technique. The effects of prepared tablets by using natural polymers were evaluated for pre compression parameters, uniformity of content, assay and in vitro drug release. Influences of different parameters like pH, agitation intensity on drug release were also studied. Cefixime Trihydrate...
22. January 2016
The rate of drug release from polymer matrix-based sustained release formulations is often controlled by the thickness of a gel layer that forms upon contact with dissolution medium. The effect of formulation parameters on the kinetics of elementary rate processes that contribute to gel layer formation, such as water ingress, polymer swelling and erosion, is therefore of interest. In the present work, gel layer formation has been investigated by Magnetic Resonance Imaging (MRI), which is a...