02. July 2018
The aim of this study was to develop self-nanoemulsifying drug delivery system (SNEDDS) of bosentan using quality by design (QBD) approach with better bioavailability. The major component of the formulation vis-à-vis lipid (Capmul MCM), surfactant (LABRASOL) and co-surfactant (PEG 600) were selected on the basis of saturation solubility. Mixture of LABRASOL and PEG 600 in the ratio of 1:1 showed better nano emulsifying region as depicted by pseudo ternary phase diagram. The optimum mixture of...
30. March 2017
Abstract Albeit the rapidly evolving knowledge about tumor biochemistry enables various new drug molecules to be designed as treatments, malignant central nervous system (CNS) tumors remain untreatable due to the failure to expose the entire tumor to such therapeutics at pharmacologically meaningful quantities. Therefore, drug delivery in CNS tumors must be properly addressed, as otherwise, novel therapies will continue to fail. In this regard, nanomedicine poses an appealing platform for...
14. September 2016
Abstract The objective of present study was to explore the application of Soluplus® as a stabilizer for the preparation of febuxostat (FEB) nanocrystals using ball milling technique. Preliminary trials were performed for the selection of stabilizer from HPMC VLV, PVA, PVP K30, Poloxamer 188 and Soluplus®. Soluplus® stabilized FEB nanocrystals were found stable and had least particle size as compared to the batches prepared using other stabilizers. A systematic optimization of critical...
29. March 2016
Microcrystalline Cellulose (MCC) pellets containing highly water soluble compound A was formulated with highest pellet usable yield of 86%, aspect sphericity that is (aspect ratio less than 1.1 and roundness greater than 0.85), minimum friability of 0.33% by extrusion and Spheronization technique. A Central Composite Design (CCD) was executed to estimate the effect of formulation and process variable namely water (21-41%), spheronization time (1-9 min) and Spheronization speed (200-800) to...
12. March 2016
Objective: The objective of the current work was to develop Ivabradine hydrochloride (HCl) floating pulsatile pellets containing drug loaded calcium alginate pellets coated with pH-dependent polymer Eudragit S100 oil dispersion. Methods: Fluidized bed coating technique was used to develop pellets. A 22 factorial design was employed to study the effect of independent variables (inlet air temperature, spray rate), on dependent variables (% entrapment efficiency, % friability, and average particle...
26. December 2015
Biopolymers are naturally occurring polymeric biomolecules. They are easily accessible, relatively cheap, can be synthetically altered and biodegradable. Locust bean gum and Xanthan gum is widely used ingredient in drug formulations due to their non interacting behavior with the drug and less toxicity. Microparticle formulations of celecoxib, a COX-2 inhibitor were formulated using Locust bean gum and Xanthan gum. More
21. June 2015
Galantamine hydrobromide (GH) is an effective drug for Alzheimer's disease. It is currently delivered via the oral route, and this might cause nausea, vomiting, and gastrointestinal disturbance. In the present work, GH was formulated in a gel-type drug reservoir and then optimized by using response surface methodology (RSM) based on central composite design. More
03. May 2015
Oral salbutamol sulphate has site-specific absorption in the stomach and upper part of the small intestine. Its bioavailability is about 40% due to several factors including narrow absorption window and extensive intestinal metabolism. The aim of this study was to formulate and optimize sustained release floating tablets of salbutamol sulphate in order to improve its bioavailability and reduce its dosing frequency......