07. February 2017

Abstract Colorectal cancer (CRC) is the third most common cancer globally and the second most common cause of cancer-related deaths. Site-specific delivery of drugs leads to an increase in the availability of drugs at the targeted region. The objective of the present investigation was to develop a dually functional microparticulate colon-targeted drug delivery system of meloxicam for potential application in the prophylaxis of colorectal cancer. Chitosan microspheres were prepared by using...

27. March 2016

In “The Lives of a Cell”, L. Thomas restated a hitherto prosaic observation as a profound conjecture, i.e, that mitochondria - the earliest aerobic bacteria - may have “created” us as a ‘symbiont utilitarian layer’ for their survival. The same can be argued for the bacteria resident in the gastrointestinal system which, to put it bluntly, may have ‘created’ us in order to feed them. There are more bacteria in the human body (>500 species) than there are human cells. Most of...

03. March 2016

The purpose of this study is to characterize the properties of Eudragit® FS-based granules prepared using melt extrusion process for colonic drug delivery. 5-Aminosalicylic acid (5-ASA), theophylline, and diclofenac sodium were used as the model compounds. Drug and polymer blends were melt-extruded into thin rods using a single screw extruder. Drugs were found to be dispersed as crystalline particles in the granules. A hammer mill was used to reduce the extrudate into 16–40 mesh granules,...