30. July 2018
The number of biologics in the therapeutic development pipeline is increasing including those delivered though inhalation (Morales, 2017; Fathe, 2016). Biologics comprise a broad variety of complex macromolecules with unique physicochemical characteristics. These distinctive characteristics control their pharmacological mechanisms of action, stability, and ultimately affect their processing, formulation, and delivery requirements. This review systematically covers crucial aspects of biologic...
10. July 2017
Poster by Glatt Pharmaceutical Services & Credentis AG @EUPFI Congress in Warshaw -
15. December 2016
Abstract Solid dispersion formulations made of itraconazole (ITZ) and Soluplus® (polyethylene glycol, polyvinyl acetate and polyvinylcaprolactame-based graft copolymer abbreviated SOL) were produced using hot melt extrusion. Since ITZ possesses a water solubility of less than 1 ng/mL, the aim of this work was to enhance the aqueous solubility of ITZ, and thereby improve its bioavailability. The three formulations consisted of a simple SOL/ITZ amorphous solid dispersion (ASD), an optimized...
20. June 2016
Highlights • Ophthalmic viscoelastic devices (OVDs) were designed composed of HPC and ɩ-carrageenan (Carr). • The rheological and compressional properties of the polymer blends were characterised. • HPC and Carr were shown to physically interact in both dilute and gel states. • Binary platforms offered a wide range of rheological and compressional properties. • Platforms containing 3% HPC and 1% or 2% Carr exhibited properties advantageous for use as OVDs Read more...
03. April 2016
Microcontainers with an inner diameter of 223 μm are fabricated using the polymer SU-8, and evaluated in vitro, in situ and in vivo for their application as an advanced oral drug delivery system for the poorly water soluble drug furosemide. An amorphous sodium salt of furosemide (ASSF) is filled into the microcontainers followed by applying a lid using Eudragit L100. It is possible to control the drug release in vitro, and in vitro absorption studies show that the microcontainers are not a...