10. January 2018

Extended drug delivery offers numerous benefits compared to immediate release dosage form. Membrane coating of immediate release dosage form is an effective means of producing an extended drug delivery system. Polymers when coated alone, have limited ability to form the rate controlling membrane with good mechanical properties.

13. November 2017

Amorphous solid dispersions (SDs) are considered as one of the most effective strategies for the formulation of poorly water-soluble compounds. The active compound is dispersed in an inert carrier composed of a polymer and active excipients. Since the drug is amorphous, there is typically an increase in apparent solubility as well as dissolution rate. Various methods are employed for manufacturing of SDs, nevertheless, hot-melt extrusion (HME) has become one of the most common process techniques