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16. February 2016
This study investigates the extrusion-spheronization performance of some mixtures of co-processed κ-carrageenan and pectin (as excipient), and sodium starch glycolate (as superdisintegrant). Attention is focused with an objective to improve the mechanical stability and the dissolution rate of poorly-soluble domperidone (as a model drug). Initially co-processed κ-carrageenan- pectin excipient is prepared with different ratios of κ-carrageenan and pectin. Different marketed brands of...