03. April 2018
Overview Webinar Title: Streamlined Manufacture of Modified Release Matrix Tablets via Direct Compression Date: Tuesday, April 10, 2018 Time: 11:00 AM Eastern Daylight Time Duration: 1 hour
18. October 2017
In the drug delivery area, versatile therapeutic systems intended to yield customized combinations of drugs, drug doses and release kinetics have drawn increasing attention, especially because of the advantages that personalized pharmaceutical treatments would offer.
01. June 2017
Ethylcellulose is a widely used film-forming polymer used to impart modified-release characteristics or mask poor-tasting ingredients. Ethylcellulose is broadly accepted due to its outstanding safety profile and ease of use in conventional spray-coating equipment. Film-coating operations with ethylcellulose can be completed using solutions of ethylcellulose in organic solvents or from aqueous dispersions. - See more at: http://drug-dev.com/Main/Back-Issues/EXCIPIENT-UPDATE-SolventLess-Film-Coati
23. May 2017
Dow Pharma & Medical Solutions is bringing the brightest and best in the industry together on June 27th and 28th 2017 in Zurich, Switzerland for a two day scientific symposium dedicated to drug delivery.
09. January 2017
Abstract The purpose of this study was to compare the chemical and physical stability of amorphous solid dispersions of Ritonavir formulated with either AFFINISOL™ HPMC HME 15LV or copovidone at 3 drug loads when placed on accelerated stability testing for a period of 6 months. Additionally, dissolution performance of the resulting amorphous solid dispersions before and after stability testing was analyzed to investigate the impact of storage and drug load on performance maintenance with each...
14. November 2016
Purpose: Modified-release (MR) matrix tablets are typically produced using hydroxypropyl methylcellulose (HPMC) as rate-modifying polymer. HPMC effectively sustains release of a broad range of active pharmaceutical ingredients (APIs), but specific dissolution behavior varies depending on the API properties, excipient properties, and formulation. Recently, a new line of HPMC, METHOCEL™ DC2 grades, have been introduced to facilitate direct compression formulations given its enhanced...
22. September 2016
Colorcon and Dow Chemical have agreed to extend and broaden their Controlled Release Alliance. The Alliance currently provides controlled release technologies from Dow Pharma & Food Solutions, a business unit of Dow. From 1 January 2017 it will be extended to include Dow’s advanced technology based pharmaceutical excipients. The Alliance was announced in July 2007 to provide customised solutions, products and support services for pharmaceutical product development. The addition of new...
01. September 2016
Because it forms strong films with excellent adhesion, ETHOCEL™ Polymers have a long history in film and bead coating for controlled release applications. These polymers can offer a versatile diffusion barrier whose properties can be modified by film thickness (weight gain), level of water soluble pore-forming additives (such as METHOCEL™), plasticizer choice, solvent(s) used, or the viscosity (molecular weight) of ETHOCEL™. For multiparticulate formulations, Dow Pharma Solutions has...
05. July 2016
This technical paper studies the impact of extrusion process parameters on the performance of solid dispersions of Ritonavir, a poorly soluble antiretroviral drug, and AFFINISOL (TM) HPMC HME, a new grade of HPMC designed for hot melt extrusion. The formulation with a fixed drug: polymer ratio was extruded at different processing conditions exploring the variables of feed rate, screw speed and temperature for their impact on drug degradation, its physical state and dissolution performance of...
25. June 2016
A Solvent-Free Advanced Productivity Technology for Barrier Membrane Coatings Philadelphia, PA: Tuesday, June 21, 2016 “The global commercial launch of ETHOCEL™ HP is an exciting development for our customers, who continue to demand more efficient, sustainable solutions to help improve their products and their manufacturing,” said Marc Van Gerwen, business director for Dow Pharma & Food Solutions. “From idea to market – all in less than two years – ETHOCEL™ HP is another...