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16. February 2016
This study evaluated the feasibility of liquisolid pellets as an innovative drug delivery system to improve the dissolution rate of low solubility drugs, combining the advantageous properties of multiple-unit dosage forms and the liquisolid formulations. The effects of crospovidone (Kollidon® CL-SF) as a coating and disintegrating material (4 or 8%) and the type of non-volatile solvent, PEG 400 or Cremophor® EL, on the felodipine (model drug) dissolution profile were assessed. All liquisolid...