22. February 2018
Hot melt extrusion has gained considerable attention as a novel technique for taste masking of bitter APIs. The aim of this study was to investigate whether hot melt extrusion could be used to develop taste masked formulations of isoniazid and also to evaluate and correlate different taste assessment methods Two polymers with different physico-chemical properties, Soluplus and Eudragit E-PO were chosen as carriers for the drug. Eudragit E-PO has already been widely used for taste masking due to...
16. January 2017
Introduction Palatability of liquid medicines is a recognised challenge within the paediatric population Acceptability: “The overall ability of the patient and its caregiver to use the medicine as intended” Patient needs must be met when medicines are designed Patient acceptability of a medicinal product is likely to have a significant impact on adherence and consequently, on its safety and efficacy. Currently no guidance of how ‘acceptability’ should be measured in an...
16. January 2017
INTRODUCTION Dissolution of oral dosage forms depends on the GI tract physiological conditions, and definition of the dissolution profile in conditions that reflect the in vivo GI environment can lead to accurate prediction of the in vivo performance (1). Whenever IVIVCs are achieved clinical studies assessing product bioavailability can be reduced in number and size and this aspect is of primary importance for paediatric patients (2). Successful predictions of the in vivo performance of drugs...
29. March 2016
European Paediatric Formulation Initiative (EuPFI) Annual Conference 20th – 22nd September 2016 in Lisbon, Portugal at Hotel Novotel Lisboa. This Conference Series organised by the International Association for Pharmaceutical Technology (APV) is the ideal forum to discuss and debate the issues/challenges of development of age appropriate dosage forms. The programme for the EuPFI meeting is typically designed around the workstreams that comprise the EuPFI activity;, Administration devices, Age...
25. February 2016
[Alcohol, alpha-Cyclodextrin, Aspartame, Benzalkonium Chloride, Benzoic Acid, Benzyl Alcohol, beta-Cyclodextrin, Butylated Hydroxyanisole, Butylparaben, Carboxymethylcellulose, Carboxymethylcellulose Sodium, Crospovidone, Ethylparaben, gamma-Cyclodextrin, Glyceryl Monocaprylate [Capmul MCM C8], Hypromellose, Lactose, Mannitol, Methylparaben, Microcrystalline Cellulose, Polyethylene Glycol, Polysorbate 20, Polysorbate 40, Polysorbate 60, Polysorbate 65, Polysorbate 80, Povidone, Propylene...
09. July 2015
The 7th EuPFI conference is the networking platform for all involved in paediatric drugs. Meet more than 100 colleagues from authorities, industry and universities to discuss hot topics and have a look at the newest research outcome in the poster presentations. Early bird deadline for registrations: 15 July 2015
08. June 2015
The STEP stands for Safety and Toxicity of Excipients for Paediatrics. The Safety and Toxicity of Excipients for Paediatrics (STEP) Database is a user-designed resource developed by European Paediatric Formulation Initiative (EuPFI) and United States Paediatric Formulation Initiative (USPFI) in collaboration for storage and rapid/effortless access to the safety and toxicological data of excipients that is scattered over various sources and presents it in one freely accessible source. It is a...
04. May 2015
It is a great pleasure and privilege for European Paediatric Formulation Initiative to invite you to the 7th annual conference on "Formulating Better medicines for Children", which will be held in Antwerp, Belgium, September 16th -17th 2015 in partnership with APV. http://eupfi.org/Conference%202015/default.htm