13. September 2018
This work demonstrates the feasibility of the extemporaneous preparation of maltodextrins orodispersible films (ODF) by hot-melt ram-extrusion 3D printing. This method consists of three simple technological operations which can be also implemented in a pharmacy setting. First, maltodextrins, drug, and other excipients are mixed in a mortar and wetted with the plasticizer (i.e. glycerine). Then, the mixture is fed in the chamber of the ram-extruder and heated. ODF are individually printed on the...
13. April 2018
Current global vaccination programs are challenged by costs associated with vaccine cold chain storage and administration. A solid, thermally stable oral dosage form for vaccines would alleviate these costs but is difficult to produce due to general vaccine instability and the complication of bypassing the gastric barrier. We developed a novel consecutive spray drying method that is suitable for use with biologics and employs Eudragit L100 polymer as the enteric coating. More specifically, in...
25. July 2016
Abstract Edible films from the blending hydroxypropyl methylcellulose (HPMC) with hydroxypropyl starch (HPS) have been developed. This work focuses on the relationship between morphologies and mechanical properties of such systems. To aid understanding of blend morphology, a new technique used to identify the two phases through dying of the HPS by iodine has been developed, which provided a simple and convenient way to clearly distinguish between HPMC and HPS phases. It was found that the blend...
14. June 2016
Heat sealing property of self-supporting edible films based on corn starch and a functional polysaccharide, such as amylose (AM), methylcellulose (MC) or hydroxypropylmethylcellulose (HPMC) was evaluated. Films were prepared in the laboratory by casting and heat sealed at 85–166 °C by an impulse heat sealer. Irrespective of film composition, sealing temperature influenced the seal strength. Films sealed at temperature <143 °C showed peeling mode failure attributing to weak seal strength,...