16. January 2018

We adopt a Quality by Design (QbD) paradigm to better control the mechanical prop- erties of tablets. To this end, the effect of particle size distribution, lubricant concentra- tion, and mixing time on the tensile strength and elastic modulus of tablets is studied. Two grades of lactose, monohydrate and spray-dried, are selected. Tablets are compressed to different relative densities ranging from 0.8 to 0.94 using an instrumented compaction simulator.