20. March 2017

Abstract Rifampicin-loaded submicron-sized particles were prepared through supercritical anti-solvent process using ethyl cellulose as polymeric encapsulating excipient. Ethyl acetate and a mixture of ethyl acetate/dimethyl sulfoxide (70/30 and 85/15) were used as solvents for both drug and polymeric excipient. When ethyl acetate was used, rifampicin was crystallized separately without being embedded within the ethyl cellulose matrix while by using the ethyl acetate/dimethyl sulfoxide mixture,...

20. July 2016

Abstract Objective: A novel multiparticulate system for the gastric delivery of Diltiazem (DTZ) was developed for effective treatment of hypertension. Materials and methods: Floating microspheres of ethylcellulose and Eudragit loaded with DTZ were successfully developed and evaluated for their gastro-retentive and controlled-release properties. The effect of various process variables on the particle morphology, micromeritic properties, in vitro floating behavior, percentage drug entrapment, and...

15. March 2016

Abstract: The purpose of the present study was to prepare floating matrix tablets of clarithromycin employing simplex lattice design. Hydroxypropyl methylcellulose (HPMC) and Ethyl Cellulose (EC) were used as matrix forming agents; sodium bicarbonate and citric acid as effervescence producing agents. Simplex lattice design was used as optimization technique employing three independent formulation variables viz. concentration of HPMC (X1), Citric Acid (X2), EC (X3) whereas floating lag time,...

02. March 2016

Aim: To evaluate possible interaction between apple cider vinegar (ACV) which is the most frequent used active ingredient of diet pills with 20 different excipients. Materials and Methods: The pure drug ACV and drug-excipient powder mixtures which were stored under the condition of 40°C and 75% relative humidity for a period of 21-day and interaction were seen by using modern instrumental technique high-performance liquid chromatography, Fourier transmission infrared and differential scanning...

29. February 2016

The purpose of the present investigation was the preparation and evaluation of gastro-retentive floating drug delivery system for anti-diabetic drug metformin hydrochloride that would retain the drug in stomach and continuously release the drug in controlled manner up to a predetermined time leading to improve bioavailability. The microspheres were prepared by oil-in-oil emulsion solvent evaporation technique using ethyl cellulose, methacrylic acid copolymer (Eudragit RS100, Eudragit RSPO and...

18. January 2016

The objective was to formulate itopride HCl (ITP) extended release matrix-coated pellets by extrusion–spheronization and to investigate the influence of concentration and viscosity grade of different polymers on release of a highly water soluble drug. The matrix pellet formulations consisted of polymers (10–30%) like hydroxypropyl methylcellulose (HPMC K4M, K15M, and K100M), ethyl cellulose (EC-7 cps), microcrystalline cellulose (10–30%) and a fixed quantity of lactose (10%). More

13. November 2015