08. August 2018
The main purpose of this study was to investigate the influence of ethylcellulose (EC) coating and curing conditions on the quality attributes of pharmaceutical pellets prepared using a quality by design (QbD) approach. The drug release rate of methimazole, a freely soluble model drug, was evaluated extensively together with the mechanical strength and true density of the coated pellets. Moreover, the thermal and spectroscopic properties, as well as the surface characteristics were studied...
10. March 2018
Mucoadhesive tablets for administration in buccal mucosa are unconventional formulations with many technological attractions. However there is no standardization of information for its formulation. The present article aims to evaluate, by means of a systematic review with meta-analysis, the data related to the final quality of this technology.
19. February 2018
The objective of this study was to assess the efficacy and the capability of a novel ethylcellulose-based dry-coating system to obtain prolonged and stable release profiles of caffeine-loaded pellets. Lauric and oleic acids at a suitable proportion were used to plasticize ethylcellulose. The effect of coating level, percentage of drug loading, inert core particle size, and composition of the coating formulation including the anti-sticking agent on the drug release profile were fully...
15. February 2018
Polymer physical gels have been used in numerous practical applications within food processing, chemical, cosmetics, pharmaceutical and agricultural industries. They may be obtained on the bases of synthetic and natural polymers. Natural polymers are easily biodegradable, hence their more extensive usage within the areas where synthetic polymers have been applied so far.
11. August 2017
The goal of this study was to test the feasibility to load non-ordered, non-spherical mesoporous silica with the model drug paracetamol, and subsequently coat the loaded particles using one single pilot scale fluid bed system equipped with a Wurster insert. Mesoporous silica particles (Davisil®) with a size ranging from 310 to 500 μm and an average pore diameter of 15 nm were loaded with paracetamol to 18.8% drug content. Subsequently, loaded cores were coated with ethylcellulose to obtain...
01. June 2017
Ethylcellulose is a widely used film-forming polymer used to impart modified-release characteristics or mask poor-tasting ingredients. Ethylcellulose is broadly accepted due to its outstanding safety profile and ease of use in conventional spray-coating equipment. Film-coating operations with ethylcellulose can be completed using solutions of ethylcellulose in organic solvents or from aqueous dispersions. - See more at: http://drug-dev.com/Main/Back-Issues/EXCIPIENT-UPDATE-SolventLess-Film-Coati
28. July 2016
ABSTRACT Background: Gastroretentive floating microsphere containing Lafutidine, a second generation histamine H2–receptor antagonist were prepared by ionotropic gelation technique by using sodium alginate, HPMC K4M, ethyl cellulose as polymers, sodium bicarbonate as gas generating agent and calcium chloride as cross linking agent. Objective: To formulate a system to remain in the stomach for prolonged and predictable period in order to enhance the drug bioavailability. Method: They were...
20. July 2016
ABSTRACT The goal of this study was to utilize risk assessment techniques and statistical design of experiments (DoE) to gain process understanding and to identify critical process parameters for the manufacture of controlled release multiparticulate beads using a novel disk-jet fluid bed technology. The material attributes and process parameters were systematically assessed using the Ishikawa fish bone diagram and failure mode and effect analysis (FMEA) risk assessment methods. The high risk...
25. June 2016
The meeting of the Pharmacopoeial Discussion Group (PDG) [European Pharmacopoeia (Ph.Eur.), Japanese Pharmacopoeia (JP), and the United States Pharmacopeia (USP)] was hosted by EDQM in Strasbourg, France, 25-26 May 2016. To date, 29 of the 36 General Chapters and 49 of the 67 excipient monographs on the current work programme have been harmonised. Sign-offs at this meeting include a new monograph on Hydroxyethylcellulose and two revised monographs on Ethylcellulose & Cellulose acetate....
28. April 2016
The goal of this study was to test the feasibility to load non-ordered, non-spherical mesoporous silica with the model drug paracetamol, and subsequently coat the loaded particles using one single pilot scale fluid bed system equipped with a Wurster insert. Mesoporous silica particles (Davisil®) with a size ranging from 310 to 500 μm and an average pore diameter of 15 nm were loaded with paracetamol to 18.8% drug content. Subsequently, loaded cores were coated with ethylcellulose to obtain...