07. October 2017
Burst drug release is often considered a negative phenomenon resulting in unexpected toxicity or tissue irritation. Optimal release of a highly soluble active pharmaceutical ingredient (API) from hypromellose (HPMC) matrices is technologically impossible; therefore, a combination of polymers is required for burst effect reduction. Promising variant could be seen in combination of HPMC and insoluble Eudragits® as water dispersions. These can be applied only on API/insoluble filler mixture as...
20. September 2017
Abstract The objective of this study was to evaluate the combination of pH-dependent and time-dependent polymers on drug release in order to optimize coating for colonic delivery. Response surface methodology (RSM) based on central composite design (CCD) was employed for formulation optimization. Theophylline was used as model drug and Eudragit® FS 30D and hydroxypropyl methylcellulose (HPMC) were used as pH-dependent and time-dependent polymer, respectively. Dissolution test was carried out...
04. September 2017
Abstract The aim of this study was to develop and characterize sustained release vildagliptin (VLG) loaded Eudragit® RS-100 microspheres. The microspheres were prepared by single emulsion [oil-in-oil (O/O)] solvent evaporation method. Plackett–Burman design (PBD) was employed by using Design-Expert®Software to screen and understand impact of five independent formulation factors such as Eudragit® RS-100 (A), span-80 (B), acetone (C), methanol (D), stirring speed (E) affecting on...
29. August 2017
Electrospinning of Eudragit® FS 100 was investigated for the first time.
• Novel AC electrospinning produced excellent quality nano fibers at high throughput.
• Melt rheology of Eudragit® FS 100 was thoroughly explored.
• Eudragit® FS-based solid dispersions provided excellent control on release of poorly soluble spironolactone as pH varied.
26. March 2017
Abstract In this work, amorphous paracetamol/Eudragit® formulations for four Eudragit® (polymeric excipients) were prepared by spray drying technique. The simultaneous dissolution kinetics of paracetamol and Eudragit® from these formulations were measured as function of pH in vitro using a rotating disk system (USP II). Paracetamol dissolution mechanisms were analyzed by comparing the dissolution rates of paracetamol and excipient. It was found that a controlled paracetamol dissolution was...
16. March 2017
Abstract A doubly enteric-coated multiple-unit tablet (DET) of bisacodyl (BD) was formulated to selectively deliver the stimulant laxative to the large intestine. Solubilized BD in surfactants was adsorbed into the porous carrier and primarily coated with different combinations of pH-sensitive polymers (Eudragit S and Eudragit L) and time-dependent release polymer (Eudragit RS). BD-loaded granules were compressed into tablets and coated again with pH-sensitive polymers (Eudragit S:Eudragit L =...
15. February 2017
Abstract The purpose of this study was to develop and evaluate the berberine hydrochloride (HB) - Eudragit S100 solid dispersion to prolong the drug release by expoiting its pH-sensitivity dissolution. Solid dispersion of berberine hydrochloride (HB) with Eudragit® S100 (S100) was prepared by a solvent evaporation method. Based on the evaluating dissolution in vitro, the ratio of HB and S100 was optimized to 1:4. The solid dispersion formation of HB-S100 was characterized by XRD, DSC, and...
06. November 2016
Abstract Herbal medicines are recognized as an effective treatment of common diseases, mainly associated with oxidative stress. Therefore developing drug delivery systems of these biological active ingredients are gaining interest. Parsley (Petroselinum crispum L.) is a well-known culinary herb and its leaf contains high amount of apigenin, therefore it is suitable as a natural source of this flavonoid. Apigenin possess many health effects such as antioxidant, anti-inflammatory and anticancer...
21. June 2016
Abstract Protein stability is the most crucial factor in protein pharmaceutical preparations. Various techniques were applied for producing stable protein formulations such as spray-drying and freeze-drying. However, heating and freezing stresses are disadvantages for proteins using these methods, respectively. Accordingly, excipients have been used to preserve therapeutic effects of proteins during processing and for long period of time. Therefore, influences of Copovidone, Eudragit® RL-PO...
03. March 2016
The purpose of this study is to characterize the properties of Eudragit® FS-based granules prepared using melt extrusion process for colonic drug delivery. 5-Aminosalicylic acid (5-ASA), theophylline, and diclofenac sodium were used as the model compounds. Drug and polymer blends were melt-extruded into thin rods using a single screw extruder. Drugs were found to be dispersed as crystalline particles in the granules. A hammer mill was used to reduce the extrudate into 16–40 mesh granules,...