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24. June 2016
ABSTRACT Objective: The objective of this study is to develop extended release matrix tablet by taking mixture of chitosan and anionic polymers and then to study the drug release pattern for a low solubility drug Tramadol Hydrochloride (TH). TH has mean elimination half-life is ~6 hrs and requires dosing every 6 hrs in order to maintain optimal relief of chronic pain. So once-daily extended-release tablets are formulated by taking Chitosan (CS) and anionic polymers Eudragit-L100-55. Methods:...