11. January 2018
The oral bioavailability of poorly water-soluble active pharmaceutical ingredients (APIs) can be improved by the preparation of amorphous solid dispersions (ASDs) where the API is dissolved in polymeric excipients. Desired properties of such ASDs like storage stability, dissolution behavior, and processability can be optimized by additional excipients. In this work, the influence of so-called low-molecular-weight excipients (LMWEs) on the phase behavior of ASDs was investigated.
24. May 2017
A new mineral–polymer composite (FCC-PCL) performance was assessed to produce complex geometries
to aid in development of controlled release tablet formulations.
11. October 2016
Orally disintegrating tablets (ODTs) are a preferred dosage form compared with conventional tablets because of the numerous advantages they offer, such as rapid dissolution and fast onset of action. To maintain the porous structure needed for fast dispersion, most current ODT formulations are limited by their mechanical strength. With functionalised calcium carbonate, however, pharmaceutical manufacturers can produce ODTs that offer high mechanical strength while disintegrating twice as fast as...
23. April 2016
Multiparticulate dosage forms consist of small sub-units containing the drug and having the advantage of more uniform and predictable transit time, better distribution and less local irritation in the gastrointestinal tract, compared to single unit dosage forms [1, 2]. These multiparticulates, when designed as mucoadhesive formulations, can potentially prolong and normalize the residence time in the gastrointestinal tract, and increase oral drug bioavailability due to their adhesive...
23. September 2015
Carolina Diaz-Quijano explains how it performs in tablets, orally disintegrating tablets, and orally disintegrating granules. More