08. November 2016

This study assesses the solid-solid interactions between the commercial form of Ketoprofen (KET), a non- steroidal anti-inflammatory drug of the propionic acid class, and several widely used pharmaceutical excipients. The work was carried out on drug-excipient mixtures, in 1:1 (w:w) ratio, blended in an agate mortar at room temperature. The compatibility/incompatibility of KET with the proposed excipients was highlighted by the most commonly used analytic methods: differential scanning...

21. June 2016

Abstract Protein stability is the most crucial factor in protein pharmaceutical preparations. Various techniques were applied for producing stable protein formulations such as spray-drying and freeze-drying. However, heating and freezing stresses are disadvantages for proteins using these methods, respectively. Accordingly, excipients have been used to preserve therapeutic effects of proteins during processing and for long period of time. Therefore, influences of Copovidone, Eudragit® RL-PO...

20. March 2016

This study aims to develop a self-nanoemulsifying drug delivery system (SNEDDS) based on non-ionic surfactant mixtures to improve the oral bioavailability of efavirenz (EFZ) categorized as a class II according to the BCS, for HIV- therapy. The result of solubility studies of EFZ in various excipients utilized for construction of the pseudo ternary phase diagram containing surfactant mixtures. Surfactants in 1:1 combination are used with different co-surfactants in different ratio to delineate...