04. October 2016
Abstract Among various methods for drying pharmaceutical granules in the pharmaceutical industry, fluidized bed drying is commonly used due to its high rate of moisture removal, excellent performance in solids mixing, and heat and mass transfer. As pharmaceutical powders are typically organic materials with high resistivity, they can easily be charged due to repeated collision and separation of particles, along with particle-wall friction, in a fluidized bed dryer. This phenomenon, called...
21. June 2016
Abstract Mucoadhesive microparticles formulated in a capsule and delivered to the gastrointestinal tract might be useful for local drug delivery. However, swelling and agglomeration of hydrophilic polymers in the gastrointestinal milieu can have a negative influence on particle retention of mucoadhesive microparticles. In this work, we investigated the impact of dry-coating with nano-sized hydrophilic fumed silica on dispersibility and particle retention of mucoadhesive microparticles. As a...