27. April 2018
This article reviews regulatory considerations for companies wishing to develop drugs for delivery via the respiratory tract (e.g., by oral inhalation or intranasally) using molecules previously approved for a different therapeutic indication and/or a different delivery route. Conceptually, such repurposing has many medical and business advantages, but turning promising ideas into real products requires overcoming a number of practical challenges. Obtaining regulatory approval to market a...
26. April 2018
Are you a manufacturer of raw materials for the food, nutraceutical or pharmaceutical industry and interested to increase your product performance or functionality? Are topics like Dust free Solubility Protection Taste masking Targeted release Particle size Flowability relevant to you or for the life cycle management of your product? Then come to speak with the experts from IPC Process Center @Vitafoods Geneva Stand T167 - May 15-17, 2018. If not attending just drop us an email. Further...
20. April 2018
Are you looking for a tailored film coating for your product? pharmaexcipients offers the access to film coating experts to put together a tailored coating based on your application and needs in a fast and simple way. Just fill in the questionnaire
01. April 2018
Self-emulsifying drug delivery systems (SEDDS) have been widely employed to improve the oral bioavailability of poorly soluble drugs. In the past few years, SEDDS were extensively investigated to overcome various barriers encountered in the oral delivery of hydrophilic macromolecules (e.g., protein/peptide therapeutics and plasmid DNA (pDNA)), as well as in lowering the effect of food on drugs' bioavailability. However, the main mechanism(s) by which SEDDS could achieve such promising effects...
05. October 2017
Recently, increasing attention has been given to carotenoid bioaccessibility and bioavailability in the field of nutrition research. As a consequence of their lipophilic nature and their specific localization in plant-based tissues, carotenoid bioaccessibility and bioavailability is generally quite low in raw fruits and vegetables, since carotenoids need to be released from the cellular matrix and incorporated in the lipid fraction during digestion before being absorbed.
25. September 2017
Medicines play a key role in the diagnosis, treatment and prevention of diseases, they slow down or halt disease progression and ease symptoms of diseases. For a medicine to work properly though, it has to be used correctly, i.e. at the right dose, at the right time and by the right directions.
10. February 2017
Purpose To develop a model linking in vitro and in vivo erosion of extended release tablets under fasting and postprandial status. Methods A nonlinear mixed-effects model was developed from the in vitro erosion profiles of four hydroxypropyl methylcellulose (HPMC) matrix tablets studied under a range of experimental conditions. The model was used to predict in vivo erosion of the HPMC matrix tablets in different locations of the gastrointestinal tract, determined by magnetic marker monitoring....
26. January 2017
Abstract The interest of consumers and government organizations on improving the quality of food and its impact on human health is growing in recent years. Consuming low-calorie foodstuffs are increasingly demanded, and the presence of artificial sweeteners plays an important role not only in food but also in waste reaching the environment. Analysis of these compounds is important in assessing food safety and quality. This chapter reviews the analytical approaches for the extraction and...
13. December 2016
Abstract Carrageenan is a natural polysaccharide extracted from edible red seaweeds of Rhodophycea class. It has been used as a viscosity increasing or gelling agent for prolonged and controlled drug release, food, pharmaceuticals and other industries. However, in spite of wide range of applications, carrageenan has some drawbacks and adverse effects on the biological systems, so its modifications with natural and synthetic polymers are carried out. This review article presents different...
17. October 2016
Summary The search for better strategies to preserve foods with minimal changes during processing has been of great interest in recent decades. Traditionally, edible films and coatings have been used as a partial barrier to moisture, oxygen, and carbon dioxide through selective permeability to gases, as well as improving mechanical handling properties. The advances in this area have been breathtaking, and in fact their implementation in the industry is already a reality. Even so, there are...