23. January 2017
Abstract Although the intestinal microbial community is still incompletely understood, there is strong evidence of the benefits of using probiotics to address some medical states or conditions. As a result, the probiotics oral supplements market has exploded during the last few years. However, while their sensitivity to gastric juices, acidic pH and bile is well known, most of these oral forms would not guarantee any survival of the strains in such conditions. In this work, we have studied the...
17. November 2016
Abstract Control of drug action through formulation is a vital and very challenging topic within pharmaceutical sciences. Cellulose nanofibers (CNF) are an excipient candidate in pharmaceutical formulations that could be used to easily optimize drug delivery rates. CNF has interesting physico-chemical properties that, when combined with surfactants, can be used to create very stable air bubbles and dry foams. Utilizing this inherent property, it is possible to modify the release kinetics of the...
05. March 2016
Almost all drugs are rapidly and completely absorbed form gastrointestinal tract. But some drug having problems like first pass metabolism, low bioavailability, chances of dose dumping, unstability at colonic pH, produced gastric irritation when administered in single unit dosage form or disturbed normal colonic bacterial flora. It creates the need to design safer and effective drug delivery systems. The floating microspheres are one of the most promising multiparticulates drug delivery system...