27. August 2018

Affinisol® (Hydroxypropylmethyl cellulose) polymers with low glass-transition temperature are usually processed by Melt Extrusion and show better compressibility at lower compression pressure. This study evaluates the compaction properties and powder properties of Affinisol® Powder by the determination of physical properties like bulk/tapped density, angle of repose and loss on drying, an out-of-die compactability, axial expansion post-compression, effect of compression force on hardness of...

09. December 2017

Simulation of HME processes is a valuable tool for increased process understanding and ease of scale-up. However, the experimental determination of all required input parameters is tedious, namely the melt rheology of the amorphous solid dispersion (ASD) in question.