05. May 2018
Along with the development of novel drug delivery systems the material science is also advancing. Conventional and novel synthetic or natural excipients provide opportunities to design dosage forms of the required features including their bioavailability.
15. February 2018
The poor oral bioavailability of many active pharmaceutical ingredients (APIs) resulting from low solubility is one of the important challenges in pharmaceutical technology. Over the last two decades the number of relatively insoluble drugs has grown steadily. Nowadays it is estimated that approximately 70% of new drug candidates are characterized by poor solubility.
19. January 2018
The authors studied six different grades of HPC to determine how they performed in high-shear and fluid-bed granulation.
04. December 2017
Fused deposition modelling (FDM) 3D printing (3DP) is a revolutionary technology with the potential to transform drug product design in both the pre-clinical and clinical arena. The objective of this pilot study was to explore the intestinal behaviour of four different polymer-based devices fabricated using FDM 3DP technology in rats.
02. May 2017
Highlights
• Binder properties were correlated to granule and tablet properties.
• Groups of binders behave divergent regarding granule and tablet properties.
• Povidone based polymers seem to have another binding behaviour.
• Disintegration of tablets was explained by particle size and viscosity effects.
• Changes in particle size caused larger effects for small-sized binders on tablets.
23. May 2015
By Dan Stanton+, 11-May-2015 Recent US FDA approval of products containing the excipient HPC has driven demand, according to Nippon Soda (Nisso) which has expanded its production facility in Japan. http://www.in-pharmatechnologist.com/Ingredients/Nisso-opens-expanded-HPC-plant-on-back-of-pharma-demand