25. February 2017

Abstract Halloysite nanotubes, a biocompatible nanomaterial of 50–60 nm diameter and ca. 15 nm lumen, can be used for loading, storage and sustained release of drugs either in its pristine form or with additional polymer complexation for extended release time. This study reports the development composite tablets based on 50 wt.% of the drug loaded halloysite mixed with 45 wt.% of microcrystalline cellulose. Powder flow and compressibility properties of halloysite (angle of repose, Carr’s...

17. October 2016

Abstract Novel kappa-carrageenan (Kc)/halloysite nanotube (HNT) nanocomposite hydrogels were synthesized via physical crosslinking for the gastro-intestinal tract (GIT) release. The influence of HNT nanoparticle content on Kc/HNT hydrogel properties such as thermal, swelling, drug loading and in vitro release was examined. Thermal results revealed that the incorporation of HNT nanoparticles enhanced the thermal stability of the nanocomposite hydrogels. Also, the nanocomposite hydrogels showed...

10. February 2016

Newly discovered active macromolecules are highly promising for therapy, but poor bioavailability hinders their oral use. Microencapsulation approaches, such as protein prilling into microspheres, may enable protection from gastrointestinal (GI) enzymatic degradation. This would increase bioavailability mainly for local delivery to GI lumen or mucosa. This work’s purpose was to design a novel architecture, namely a Nanotubes-in-Microgel Oral System, by prilling for protein delivery....