Posts tagged with "Hard"



Graphical overview of production of lipid-coated mannitol core micropartiles for sustained protein release
25. April 2018
Parenteral sustained release systems for proteins which provide therapeutic levels over a longer period avoiding frequent administration, which preserve protein stability during manufacturing, storage and application and which are biodegradable and highly biocompatible in the body are intensively sought after. The aim of this study was to generate and study mannitol core microparticles loaded with a monoclonal antibody IgG1 and coated with lipid either hard fat or glyceryl stearate at different...

03. March 2017
Abstract Fenofibrate, a drug of fibrate class, is mainly used to reduce cholesterol levels in patients at risk of cardiovascular disease. However, bioavailability of fenofibrate is often low and unpredictably due to its poor solubility. Microparticle entrapped micelles (MEM) technology is a novel method of incorporating surfactants in solid dosage form for improving in vitro and in vivo performance of poorly water soluble drugs. Increasing the fenofibrate solubility by MEM technology has not...