05. March 2018
Mechanical properties of pharmaceutical materials, e.g., Young's modulus (E), indentation hardness (H), and tensile strength (σ), play an important role in powder compaction process. However, few studies investigated the relationship among these parameters and consequence for tablet compression. Using microcrystalline cellulose, a plastic material, and dibasic calcium phosphate anhydrate, a brittle material, as well as their binary mixtures, we systematically examined the relationship among the
09. February 2018
Preparation of mini buccal tablets incorporating either of the Alzheimer’s drugs, rivastigmine tartrate or donepezil hydrochloride, were developed for patients who have difficulty swallowing as a source of effervescence, by pairing the less commonly used malic acid with sodium bicarbonate in an experimentally determined (1:2) stochiometirc ratio.
06. January 2017
ABSTRACT Metformin hydrochloride is generally used to regulate blood glucose level; It is mainly used for Insulin- dependent mellitus or Type II diabetes. Type II diabetes mellitus acts by decreasing hepatic glucose output and peripheral insulin resistance. Metformin hydrochloride is a very popular high dose pharmaceutical active. It is normally made by wet granulation method. Wet granulation is more time and man power consuming method. The overall objective of the present work was to develop...
05. January 2017
ABSTRACT Quality of pharmaceutical product is very important because pharmaceuticals drugs should be safe and therapeutically active formulation performance should be consistent and predictable. Final product quality depends on all ingredients which is used for making the final product tablet. Final product tablet is made by the addition of bulk drug and excipients. The continuous evolution of the bulk drugs and excipients can only ensure the quality of final product. Moisture content of...
09. May 2016
The present research is focused on developing a novel, scaled-down approach based on the liquid droplet-powder bed interactions for the estimation of an optimal liquid to solid ratio (L/S) required in the twin screw wet granulation. A single droplet ‘powder-bed-nucleation’ process using compacted powder beds of α-lactose monohydrate (soluble) and microcrystalline cellulose (insoluble, swells upon water addition) with varying proportions of hydroxypropyl cellulose, was used to produce wet...
30. March 2016
A pharmaceutical compound was used to study the effect of batch wet granulation process parameters in combination with the residual moisture content remaining after drying on granule and tablet quality attributes. The effect of three batch wet granulation process parameters was evaluated using a multivariate experimental design, with a novel constrained design space. Batches were characterised for moisture content, granule density, crushing strength, porosity, disintegration time and...
04. February 2016
Despite the popularity of orally fast disintegrating tablets (FDTs), their formulation can sometimes be challenging, producing tablets with either poor mechanical properties or high disintegration times. The aim of this research was to enhance the properties of FDTs produced by direct compression to have both sufficient hardness to withstand manual handling, and rapid disintegration time. General multilevel factorial design was applied to optimise and evaluate main and interaction effects of...