06. April 2017

Abstract The morphology and polymorphism of mannitol particles were controlled during spray drying with the aim of improving the aerosolization properties of inhalable dry powders. The obtained microparticles were characterized using scanning electron microscopy, infrared spectroscopy, differential scanning calorimetry, powder X-ray diffraction and inhaler testing with a next generation impactor. Mannitol particles of varied α-mannitol content and surface roughness were prepared via spray...

08. July 2016

Abstract This paper highlights preliminary results related to a new dry granulation process that is run in a twin-screw extruder. This heat-activated dry granulation method can produce suitable dry granules representing an exciting new area for continuous granulation. However, the current method makes starting granulation difficult. It is believed that high compaction produces sufficient friction at the barrel wall to cause the binder to soften. Once a plug of dense granular matter is built up...

14. June 2016

Heat sealing property of self-supporting edible films based on corn starch and a functional polysaccharide, such as amylose (AM), methylcellulose (MC) or hydroxypropylmethylcellulose (HPMC) was evaluated. Films were prepared in the laboratory by casting and heat sealed at 85–166 °C by an impulse heat sealer. Irrespective of film composition, sealing temperature influenced the seal strength. Films sealed at temperature <143 °C showed peeling mode failure attributing to weak seal strength,...

29. October 2015