22. August 2016

Abstract Temperature has rarely been examined in twin-screw wet granulation despite the obvious capabilities of the extruder for operating at elevated temperatures. The present work investigates the wetting behavior of a mixture of powders with different sorption characteristics at various temperatures to explain the unique granulation behavior witnessed with high molecular weight hydroxypropyl methylcellulose in a twin-screw extruder. The work studies the twin-screw granulation of a controlled...

06. September 2015

Objective of this work was to understand the mechanism of formation of celecoxib nanocrystals in celecoxib: mannitol nanocrystalline solid dispersion (NSD). Solution of celecoxib and mannitol was spray dried in 1:1 (g:g) proportion to obtain NSD, with average crystallite size of 214.07 ± 45.27 nm. Solubility parameters of celecoxib and mannitol were 23.1 MPa1/2 and 38.5 MPa1/2, respectively, hinting their immiscibility. More