06. May 2018
In the course of application and modernization of buccal dosage forms, lyophilized sponges for transmucosal drug delivery symbolize one of the most attractive approaches. Chitosan (CS) has been extensively investigated as a forming material of different buccal dosage forms including sponges. However, CS-based buccal delivery systems suffer from many limitations like weak adhesion strength and poor tensile properties. So, for the first time, the current study focused on the polymer blending...
03. April 2017
Abstract Hyaluronic acid (HA) solutions effectively lubricate the ocular surface and are used for the relief of dry eye related symptoms. However, HA undergoes rapid clearance due to limited adhesion, which necessitates frequent instillation. Conversely, highly viscous artificial tear formulations with HA blur vision and interfere with blinking. Here, we developed an HA-eye drop formulation that selectively binds and retains HA for extended periods of time on the ocular surface. We synthesized...
29. March 2017
Abstract It was demonstrated in this study that the treatment of physical mixtures of hyaluronic acid (HA) and oncology drugs raloxifene, letrozole, and irinotecan in solid state under shear stress and deformation induces amorphization of the drug component. Such loss of crystallinity favors dispersion of drugs in HA matrix at a molecular level. Upon dissolution, the composites of poorly soluble raloxifene and letrozole form various solvated species that may include drug-HA composites, large...