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07. January 2017
ABSTRACT: Bosentan is an endothelial receptor antagonist (ERA) indicated for the treatment of Pulmonary arterial hypertension (PAH). The aim of the present study involves the development of controlled release tablets of bosentan1. The tablets were prepared to release the drug for a prolong period of time within the GIT, to enhance the bioavailability, to minimize the dosing frequency, and to improve the patient compliance2. The tablets were formulated by using various polymers like hydroxyl...
22. November 2016
Abstract The surface of hydrophilic silica particles was modified with different concentrations (2, 4, 6, 8 and 10%) of γ-methacryloxypropyltrimethoxysilane (MPTS). The hydrophobicity and hygroscopicity of unmodified and modified silica were investigated through water contact angle (WCA) tests and dynamic vapor sorption (DVS) method, respectively. The results showed that the surface properties of silica were closely related with the MPTS concentration. Within the range of MPTS concentration...
20. March 2016
The aim of this study is to propose a new electrochemical method for the evaluation of the antioxidant capacity of the pharmaceutical antioxidant excipient in drugs. The evaluation was conducted by integrity testing of DNA bases, which were modified on an electrode. Guanine was selected as the electrochemical probe. Based on the changes of the oxidation current of guanine on a modified glassy carbon electrode (GCE), the protective capacity of the antioxidant for guanine was determined. TiO2...
23. February 2016
Fast dissolving oral film of Losartan potassium were prepared and evaluated with an objective to rapid dissolution of drug and absorption which may produce the rapid onset of action in the treatment of hypertension and provides the convenient means of administration to those patient suffering from difficulty in swallowing such as paediatrics, geriatric, and uncooperative mentally ill patients and also improve the bioavailability of the drug. The fast dissolving oral film were prepared using...