27. July 2016

Abstract The aim of the presented research was the preparation and in vitro and in vivo evaluation of mucoadhesive oral films containing nystatin. Multivariate data analysis was used to evaluate an innovative approach, in which a combination of different mucoadhesive polymers was employed. The purpose of this was to assess the effects of such a combination on non-woven insoluble carmellose textile as a drug-release modifier in the structure of the film. It was observed that the mucoadhesive...

19. May 2016

Investigational drugs are increasingly becoming less soluble in aqueous media thus presenting real challenges during development. Previous work has successfully demonstrated the manufacturing of pharmaceuticals using fluidized-bed (FB) impregnation of APIs onto porous carriers. This study demonstrates the usefulness of FB impregnation in formulating poorly-soluble drugs. We show that dissolution of Fenofibrate is greatly improved by FB impregnation onto Neusilin®, a synthetic amorphous form of...